Here's the Fort Garry, Winnipeg's classic old CNR hotel which has been independently owned since 1979.
thousandwonders.net
Winnipeg had a couple of other notable railway hotels, including the longstanding Royal Alexandra Hotel next to the CPR station. The Royal Alex had the misfortune of being located a down at the heels area a bit far from Portage and Main, in what would eventually become Winnipeg's skid row. Once the bottom fell out of intercity railway traffic, its fate was sealed and the Royal Alex was demolished in 1971.
winnipegfreepress.com
There was also the Northern Pacific's short-lived Manitoba Hotel near Portage and Main which burned down in 1899, only nine years after it was built.
mhs.mb.ca
Likely the best-known railway hotel in the province outside of Winnipeg was Brandon's Prince Edward Hotel. It was a CN hotel and there was a small railway station attached to it for local trains. It was demolished back in 1980.
ebrandon.ca