Daily. I use it to go to work and for most of my trips that are farther than walking distance. For things I can't easily do on SkyTrain (or sometimes buses), I use ZipCar.
People who aren't regular transit users would be amazed at how much shopping I've carried onto the SkyTrain after shopping trips to Costco (@Stadium) or Home Depot/Canadian Tire (@Broadway-City Hall.) I'm considerate enough not to do that when it is busy though.
I've tried owning a car but simply don't have the need for it, since I generally prefer transit to driving&parking in Vancouver. When I last owned a car, a tank of gas would last me 3 months and weeds started growing from under my hood (true story!)