In terms of local significance, I think the various businesses that sell prints for the local market are a good indication.
On the right, there is the Roman Catholic Basilica of St. John the Baptist, The Rooms, Cabot Tower, Murray Premises, Scotia Plaza, Atlantic Place.
In the middle is, starting at the top left and going in rows...
NLTA Building (?), Fluvarium, Confederation Building, Logy Bay Mosque, Aquaarena, MUN Education Building, MUN Clocktower, MUN something, Central Fire Station, Churchill Square, Beth El Synagogue, Mary Queen of the World Regional High School/Holy Heart Theatre (same building), Memorial Dominion, Royal St. John's Regatta Boathouse, The Rooms, Basilica, Bannerman Park Gazebo, Colonial Building, Her Majesty's Penitentiary, Southcott Hall, Delta, Anglican Cathedral of St. John the Baptist, Republic of Doyle house, LSPU Hall, I have no fucking clue (City Hall?), Supreme Court of Newfoundland and Labrador, Fred's Records, Devon House, Battery Hotel, Murray Premises, Scotia Plaza, Ziggy Peelgoods Chip Wagon, Raymond's Restaurant, Johnson Geo Centre, Cabot Tower.