I myself have always loved Dunsmuir at Burrard.
It honestly has a very strong big city feel, with the Burrard skytrain station / park (subway) and Bental 3, 4, 5, Park Place, Hyatt Hotel, and Royal Bank tower all surrounding it (and now the Shangri-La popping up behind the Concrete Waffle building).
Then, in the spring all the cherry trees bloom and it is amazing.
I know this analogy is used a lot, but it does have a Tokyo feel to it (and by that I mean it feels similar to some of the newer business districts with the subways at the base).
Google Earth does not do it justice:
PS - I don't know why but the Bental complex is probably my favorite office complex in Canada, Bental 3 and 4 have a very monolithic presence, the slow tappers towards the top add a great aspect when standing at their base, and of course the dark glass adds some good variety to Vancouver. Also, Bental 5 is just beautiful!